Tumor suppressor and hepatocellular carcinoma

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent ...

HOXD10 acts as a tumor suppressor in hepatocellular carcinoma

Objective: HOXD10, which regulates and maintains cell-differentiated phenotype, has involved in the tumorigenesis of many human cancers. However, the expression patterns and biological functions of HOXD10 in hepatocellular carcinoma (HCC) remain to be unclear. Therefore, we investigated the clinical and biological functions of HOXD10 in HCC in this work. Methods: HOXD10 expression was detected ...

Tumor suppressor XAF1 induces apoptosis, inhibits angiogenesis and inhibits tumor growth in hepatocellular carcinoma

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1), a XIAP-binding protein, is a tumor suppressor gene. XAF1 was silent or expressed lowly in most human malignant tumors. However, the role of XAF1 in hepatocellular carcinoma (HCC) remains unknown. In this study, we investigated the effect of XAF1 on tumor growth and angiogenesis in hepatocellular cancer cells. Our results showed ...

Hepatocellular Carcinoma in Sheep